In the "Resident Evil" remake, the laboratory beneath the Spencer Mansion is a dark, claustrophobic environment filled with broken scientific equipment and leaking containment units, exuding a foreboding atmosphere. Key areas include the main lab with workstations and computer terminals, testing labs with medical equipment, the power room for restoring facility operations, the incubation room with monstrous experiments, and the secure bioweapons storage. The climactic battle against the Tyrant occurs in a large, sterile chamber, requiring players to utilize their skills and resources amidst the chaos of the facility's self-destruct sequence. The lab's decayed high-tech aesthetic and ominous sound design enhance the tension, culminating in a dramatic escape that reveals the full extent of Umbrella Corporation's unethical experiments.